Alzheimer's disease (AD)
is a common age-associated neurodegenerative disorder, clinically characterized
by progressive memory disorder and decline in cognitive function, which typically
begins with dementia.
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| Alzheimers Disease |
The number of people with
AD worldwide in 2006 was estimated at 26.6 million and is predicted to nearly
quadruple by 2050. The key pathological changes associated with AD brain tissue
are the accumulation of intracellular neurofibrillary tangles (NFTs) and
abnormally aggregated ‘reactive’ proteins like β amyloid (Aβ) plaques and tau.
Several elements, such as senile plaques, neurofibrillary tangles (NFTs),
abnormally aggregated ‘reactive’ proteins like β amyloid (Aβ) and tau, brain
inflammation and exposure to aluminum has already shown the development of AD.
Brain derived neurotrophic factor (BDNF) gene is supposed to be one of the
important genes, playing a significant role in AD progression. However, as a
complex disorder, the neuropathological etiology of AD mentioned above are not
due to the gene itself, but are also supposed to be associated with the
combined interaction between genes and environmental factors. Read more>>>>>>>>
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